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Off-target activity may vary by concentration and species

Those with abnormal red blood cells (megaloblastic anemia) should not take frequent B12 injections

Stopping semaglutide entirely leads to weight regain in the majority of cases

Isoniazid (INH), a tuberculosis medication, and hydralazine, used for hypertension, both form complexes with pyridoxal 5-phosphate or otherwise interfere with vitamin B metabolism, leading to functional vitamin B deficiency

While semaglutide is frequently touted as a miracle weight loss drug on social media, it may cause side effects like fatigue and brain fog or gastrointestinal issues like nausea, diarrhea, and constipation (5)

Important: Patients with Leber hereditary optic neuropathy should not take methyl B12 shots